What are the chances of having a baby with sickle cell disease?

When BOTH parents have sickle cell trait (AS), the child may inherit:

  • two normal hemoglobin genes, or
  • one normal hemoglobin gene and one sickle cell gene, or
  • two sickle cell genes

With EACH pregnancy there is a:

  • 25% chance that the baby's red blood cells will be normal (AA).
  • 50% chance that the baby will have sickle cell trait (AS).
  • 25% chance that the baby will have sickle cell disease (SS).

Both parents with sickle cell trait

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